CYP4A43P

Across TCGA pan-cancer cohorts, CYP4A43P RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated CYP4A43P data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CYP4A43P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYP4A43P expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

SKCM, STAD, and LUSC are the cancer types where CYP4A43P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	All	0.058	0.757	<.001	54	view →
STAD	DFS	Tertile	All	0.242	0.719	<.001	45	view →
LUSC	OS	Tertile	II,III,IV	0.250	0.778	.007	27	view →
LIHC	DFS	Tertile	All	0.040	0.553	<.001	27	view →
KIRC	DFS	Tertile	IV	0.127	0.630	.039	18	view →
UCEC	DFS	Tertile	All	0.709	0.901	.008	18	view →
HNSC	DFS	Tertile	IV	1.000	0.305	.026	15	view →
ESCA	DFS	Tertile	III,IV	1.000	0.277	.028	15	view →
OV	OS	Tertile	III,IV	0.428	0.299	.039	12	view →
THCA	DFS	Tertile	II,III,IV	0.558	0.877	.042	9	view →
LUAD	OS	Tertile	All	0.559	0.335	.030	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

CYP4A43P–SKCM (DFS)

Open the SKCM breakdown →