CYP4A22

Across TCGA patient cohorts, CYP4A22 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4A22-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Notch1. Each is linked with CYP4A22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4A22-to-partner and partner-to-CYP4A22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CYP4A22-low versus CYP4A22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4A22→partner) and Y-score (partner→CYP4A22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.150	-1.687	.036	.044	3	2
UCEC	MEK1 →	+0.512	+4.000	<.001	<.001	3	2
UCEC	Notch1 →	+0.189	+2.335	.001	.018	3	2
UCEC	ATM →	-0.623	-2.321	.001	.034	3	2
UCEC	eIF4G →	+0.301	+2.999	.022	.035	3	1
UCEC	FoxM1 →	+0.385	+4.000	<.001	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK_pT183_Y185 by CYP4A22 expression — UCEC

Explore this box plot interactively →