CYP4A22

Across TCGA cell cohorts, CYP4A22 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CYP4A22-associated genes across cancer lineages are ACER1, PSG6, and FDCSP. Each is linked with CYP4A22 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4A22-to-partner and partner-to-CYP4A22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by CYP4A22-low versus CYP4A22-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4A22→partner) and Y-score (partner→CYP4A22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ACER1 →	+0.080	+4.044	<.001	.009	3	1
LUNG_SCLC	PSG6 →	+0.082	+4.523	<.001	.003	3	1
LUNG_SCLC	FDCSP →	+0.333	+4.044	<.001	.009	3	1
LUNG_SCLC	SPANXN5 →	+0.070	+4.269	<.001	.005	3	1
LUNG_SCLC	PRB1 →	+0.052	+4.523	<.001	.003	3	1
SKIN	MMP26 →	+0.016	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ACER1 by CYP4A22 expression — LUNG_SCLC

Explore this box plot interactively →