Across TCGA patient cohorts, CYP4A11 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4A11-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, GSK-3_pS9, and IGFBP2. Each is linked with CYP4A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4A11-to-partner and partner-to-CYP4A11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4A11→partner) and Y-score (partner→CYP4A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.477	+3.179	.019	.010	3	2
UCEC	GSK-3_pS9 →	-0.480	-2.115	.003	.017	3	1
UCEC	IGFBP2 →	-0.577	-2.999	.027	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-2.584	.005	.010	3	1
UCEC	JNK2 →	+0.275	+2.415	<.001	.003	3	1
UCEC	Ku80 →	+0.290	+3.100	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

CYP4A11 survival (RNA) · tumor vs normal (RNA) · all CYP4A11 data types