Across TCGA cell cohorts, CYP4A11 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP4A11-associated genes across cancer lineages are PLA2G2D, GPR31, and DPEP2NB. Each is linked with CYP4A11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4A11-to-partner and partner-to-CYP4A11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4A11→partner) and Y-score (partner→CYP4A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PLA2G2D →	+0.015	+4.459	<.001	.001	3	1
LIVER	GPR31 →	+0.019	+3.977	.001	.006	3	1
LIVER	DPEP2NB →	+0.043	+3.977	<.001	.006	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	KLHDC7B →	+0.808	+3.707	<.001	.001	3	1
LARGE_INTESTINE	CCDC54 →	+0.140	+4.222	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

CYP4A11 survival (RNA) · tumor vs normal (RNA) · all CYP4A11 data types