CYP46A1

Across TCGA patient cohorts, CYP46A1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,829 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CYP46A1-associated proteins across cancer lineages are SARM1, EML1, and DOCK1. Each is linked with CYP46A1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CYP46A1-to-partner and partner-to-CYP46A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP46A1 versus SARM1 in UCEC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP46A1→partner) and Y-score (partner→CYP46A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SARM1 →	+0.534	+0.429	<.001	<.001	3	7
UCEC	EML1 →	+0.704	+0.504	<.001	<.001	3	6
BRCA	DOCK1 →	+0.303	+0.268	<.001	<.001	3	5
UCEC	FERMT2 →	+0.641	+0.385	<.001	<.001	3	5
UCEC	GSPT1 →	-0.275	-0.558	<.001	<.001	3	5
BRCA	PURA →	+0.432	+0.323	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,829 associations by consensus.

CYP46A1 vs SARM1 — UCEC

Explore this scatter interactively →