CYP46A1

Across TCGA patient cohorts, CYP46A1 mutation is significantly associated with the RNA expression of many other genes, with 2,718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP46A1-associated genes across cancer lineages are RNU6-13P, MYO15B, and C4orf46. Each is linked with CYP46A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP46A1-to-partner and partner-to-CYP46A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-13P grouped by CYP46A1-low versus CYP46A1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP46A1→partner) and Y-score (partner→CYP46A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-13P →	+0.223	+3.440	.002	.009	3	3
UCEC	MYO15B →	-0.578	-2.415	.003	.003	3	3
SKCM	C4orf46 →	+0.523	+2.279	.007	.005	3	3
UCEC	MAPK1 →	+0.441	+1.595	.003	.003	3	2
UCEC	RTCB →	+0.419	+2.169	.002	.009	3	2
UCEC	JOSD1 →	+0.387	+3.831	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,718 associations by consensus.

RNU6-13P by CYP46A1 expression — HNSC

Explore this box plot interactively →