CYP46A1

Across TCGA cell cohorts, CYP46A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,209 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CYP46A1-associated GO terms across cancer lineages are Regulation of macroautophagy, Negative regulation of myoblast fusion, and Golgi vesicle transport. Each is linked with CYP46A1 in more than 12 cancer types. Because this analysis shows association rather than direction, both CYP46A1-to-partner and partner-to-CYP46A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macroautophagy grouped by CYP46A1-low versus CYP46A1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP46A1→partner) and Y-score (partner→CYP46A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of macroautophagy →	+0.100	+0.608	<.001	.001	3	13
STOMACH	Negative regulation of myoblast fusion →	+0.172	+0.579	<.001	.002	3	12
STOMACH	Golgi vesicle transport →	+0.093	+0.510	.001	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Vesicle targeting, to, from or within Golgi →	+0.111	+0.261	<.001	.004	2	12
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.109	+0.375	<.001	<.001	3	11
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.116	+0.428	<.001	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,209 associations by consensus.

Regulation of macroautophagy by CYP46A1 expression — STOMACH

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