CYP46A1

Across TCGA cell cohorts, CYP46A1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP46A1-associated genes across cancer lineages are CRP, TMCO5A, and CRYBB1. Each is linked with CYP46A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP46A1-to-partner and partner-to-CYP46A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRP grouped by CYP46A1-low versus CYP46A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP46A1→partner) and Y-score (partner→CYP46A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRP →	+0.072	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	CRYBB1 →	+0.021	+4.736	.003	.009	3	1
BLOOD_Leukemia	GUCA1C →	+0.034	+4.969	<.001	.003	3	1
BLOOD_Leukemia	LCE5A →	+0.292	+4.152	<.001	.009	3	1
BLOOD_Leukemia	PLCXD3 →	+0.019	+5.149	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CRP by CYP46A1 expression — LARGE_INTESTINE

Explore this box plot interactively →