CYP3A7

Across TCGA patient cohorts, CYP3A7 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP3A7-associated genes across cancer lineages are TFRC, MSH2, and 4E-BP1_pT70. Each is linked with CYP3A7 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP3A7-to-partner and partner-to-CYP3A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by CYP3A7-low versus CYP3A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A7→partner) and Y-score (partner→CYP3A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.534	+2.906	.017	.001	3	3
UCEC	MSH2 →	-0.339	-3.433	<.001	.005	3	2
UCEC	4E-BP1_pT70 →	+0.126	+2.459	.010	.019	3	2
UCEC	Cyclin-B1 →	+0.620	+3.169	.009	.019	3	2
SKCM	PREX1 →	-0.279	-1.567	.029	.035	3	2
SKCM	Smac →	+0.238	+1.602	.024	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

TFRC by CYP3A7 expression — UCEC

Explore this box plot interactively →