CYP3A7

Across TCGA cell cohorts, CYP3A7 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,804 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP3A7-associated GO terms across cancer lineages are Oxidative demethylation, Demethylation, and Positive regulation of calcium ion transmembrane transport. Each is linked with CYP3A7 in more than 10 cancer types. Because this analysis shows association rather than direction, both CYP3A7-to-partner and partner-to-CYP3A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative demethylation grouped by CYP3A7-low versus CYP3A7-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A7→partner) and Y-score (partner→CYP3A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Oxidative demethylation →	-0.206	-0.262	<.001	.002	2	11
URINARY_TRACT	Demethylation →	-0.112	-0.530	<.001	<.001	3	8
KIDNEY	Positive regulation of calcium ion transmembrane transport →	-0.116	-0.269	<.001	.006	3	7
BLOOD_Leukemia	Mycotoxin metabolic process →	-0.120	-0.239	<.001	.004	3	5
BLOOD_Leukemia	Aflatoxin metabolic process →	-0.120	-0.239	<.001	.004	3	5
BLOOD_Lymphoma	Regulation of RNA splicing →	+0.094	+0.230	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,804 associations by consensus.

Oxidative demethylation by CYP3A7 expression — BONE

Explore this box plot interactively →