CYP3A7

Across TCGA cell cohorts, CYP3A7 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYP3A7-associated genes across cancer lineages are KRTAP4-9, H1-1, and BHMT. Each is linked with CYP3A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP3A7-to-partner and partner-to-CYP3A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-9 grouped by CYP3A7-low versus CYP3A7-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A7→partner) and Y-score (partner→CYP3A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KRTAP4-9 →	+0.162	+5.169	<.001	.005	3	1
SKIN	H1-1 →	+0.280	+3.679	<.001	.005	3	1
SKIN	BHMT →	+0.139	+3.716	<.001	.003	3	1
SKIN	FXYD4 →	+0.080	+3.562	<.001	.002	3	1
SKIN	OR6T1 →	+0.010	+3.700	<.001	.009	3	1
SKIN	IFNL2 →	+0.017	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

KRTAP4-9 by CYP3A7 expression — BREAST

Explore this box plot interactively →