CYP3A5

Across TCGA patient cohorts, CYP3A5 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,126 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CYP3A5-associated proteins across cancer lineages are EPB41L1, FES, and GIMAP8. Each is linked with CYP3A5 in more than 5 cancer types. Because this analysis shows association rather than direction, both CYP3A5-to-partner and partner-to-CYP3A5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP3A5 versus EPB41L1 in HNSC, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A5→partner) and Y-score (partner→CYP3A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EPB41L1 →	+0.890	+0.951	<.001	<.001	3	6
GBM	FES →	-0.333	-0.451	<.001	<.001	3	5
GBM	GIMAP8 →	-0.491	-0.554	<.001	<.001	3	5
LSCC	ZKSCAN1 →	+0.349	+0.706	<.001	<.001	3	5
UCEC	POF1B →	+1.126	+1.153	<.001	<.001	3	5
GBM	PTPRC →	-0.778	-0.689	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,126 associations by consensus.

CYP3A5 vs EPB41L1 — HNSC

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