CYP3A5

Across TCGA patient cohorts, CYP3A5 protein abundance is significantly associated with the RNA expression of many other genes, with 2,873 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CYP3A5-associated genes across cancer lineages are VWA5A, MANSC1, and NUP107. Each is linked with CYP3A5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP3A5-to-partner and partner-to-CYP3A5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP3A5 versus VWA5A in COAD, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A5→partner) and Y-score (partner→CYP3A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	VWA5A →	+0.898	+0.701	<.001	.006	3	2
COAD	MANSC1 →	+0.545	+0.563	.008	.008	3	2
COAD	NUP107 →	-0.403	-0.712	.002	.005	3	2
COAD	GBP1 →	-0.797	-0.535	.005	.007	3	2
PDAC	PDE11A →	+0.805	+1.095	<.001	<.001	3	2
PDAC	VILL →	+1.198	+0.915	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,873 associations by consensus.

CYP3A5 vs VWA5A — COAD

Explore this scatter interactively →