CYP3A5

Across TCGA cell cohorts, CYP3A5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,982 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP3A5-associated GO terms across cancer lineages are Oxidative demethylation, Mycotoxin metabolic process, and Aflatoxin metabolic process. Each is linked with CYP3A5 in more than 13 cancer types. Because this analysis shows association rather than direction, both CYP3A5-to-partner and partner-to-CYP3A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative demethylation grouped by CYP3A5-low versus CYP3A5-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A5→partner) and Y-score (partner→CYP3A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Oxidative demethylation →	-0.185	-0.486	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Mycotoxin metabolic process →	-0.336	-1.489	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Aflatoxin metabolic process →	-0.336	-1.489	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Fatty acid beta-oxidation →	+0.065	+1.205	<.001	<.001	3	10
PANCREAS	Vesicle budding from membrane →	+0.061	+2.339	.005	.004	2	10
SOFT_TISSUE	Demethylation →	-0.102	-0.559	<.001	<.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,982 associations by consensus.

Oxidative demethylation by CYP3A5 expression — CNS

Explore this box plot interactively →