CYP3A43

Across TCGA patient cohorts, CYP3A43 mutation is significantly associated with the RNA expression of many other genes, with 2,655 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP3A43-associated genes across cancer lineages are CDH12P3, MCAT, and MIR520E. Each is linked with CYP3A43 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP3A43-to-partner and partner-to-CYP3A43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH12P3 grouped by CYP3A43-low versus CYP3A43-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A43→partner) and Y-score (partner→CYP3A43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDH12P3 →	+0.049	+2.365	<.001	.003	3	3
UCEC	MCAT →	+0.378	+3.593	.005	.001	3	3
BLCA	MIR520E →	+0.227	+4.296	<.001	.006	3	2
SKCM	DAPK3 →	+0.516	+2.465	<.001	<.001	3	2
UCEC	HDGFL2 →	+0.462	+2.606	.001	.005	3	2
SKCM	ATG4B →	+0.388	+2.424	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,655 associations by consensus.

CDH12P3 by CYP3A43 expression — SKCM

Explore this box plot interactively →