CYP3A43

Across TCGA patient cohorts, CYP3A43 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP3A43-associated genes across cancer lineages are Caspase-7-cleavedD198, FOXO3a_pS318_S321, and MEK1. Each is linked with CYP3A43 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP3A43-to-partner and partner-to-CYP3A43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CYP3A43-low versus CYP3A43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A43→partner) and Y-score (partner→CYP3A43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.815	+2.321	<.001	.006	3	2
UCEC	FOXO3a_pS318_S321 →	-0.109	-2.690	.034	.006	3	1
UCEC	MEK1 →	+0.536	+3.700	<.001	.001	3	1
UCEC	MIG-6 →	+0.088	+2.999	.032	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.566	-3.584	.002	.002	3	1
UCEC	PCNA →	+0.316	+3.000	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-7-cleavedD198 by CYP3A43 expression — UCEC

Explore this box plot interactively →