CYP3A43

Across TCGA cell cohorts, CYP3A43 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,003 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP3A43-associated GO terms across cancer lineages are Cardiac muscle cell action potential involved in contraction, COPII-coated vesicle cargo loading, and Visual perception. Each is linked with CYP3A43 in more than 5 cancer types. Because this analysis shows association rather than direction, both CYP3A43-to-partner and partner-to-CYP3A43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cardiac muscle cell action potential involved in contraction grouped by CYP3A43-low versus CYP3A43-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A43→partner) and Y-score (partner→CYP3A43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cardiac muscle cell action potential involved in contraction →	-0.139	-0.014	.008	.004	3	6
BLOOD_Leukemia	COPII-coated vesicle cargo loading →	+0.060	+0.108	<.001	.001	3	5
OVARY	Visual perception →	-0.039	-0.035	.001	.007	3	4
LARGE_INTESTINE	Notch receptor processing →	+0.087	+0.045	.001	.009	3	4
UPPER_AERODIGESTIVE_TRACT	Golgi transport vesicle coating →	+0.098	+0.041	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	COPI coating of Golgi vesicle →	+0.098	+0.041	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,003 associations by consensus.

Cardiac muscle cell action potential involved in contraction by CYP3A43 expression — PANCREAS

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