CYP3A43

Across TCGA cell cohorts, CYP3A43 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP3A43-associated genes across cancer lineages are MBD3L5, CXorf51A, and ITGAD. Each is linked with CYP3A43 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP3A43-to-partner and partner-to-CYP3A43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L5 grouped by CYP3A43-low versus CYP3A43-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A43→partner) and Y-score (partner→CYP3A43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	2
SKIN	CXorf51A →	+0.459	+4.095	<.001	.009	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.023	+3.614	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MBD3L5 by CYP3A43 expression — SKIN

Explore this box plot interactively →