CYP3A4

Across TCGA patient cohorts, CYP3A4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,026 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CYP3A4-associated proteins across cancer lineages are CRYBG3, NRBF2, and PPP1R18_S224. Each is linked with CYP3A4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CYP3A4-to-partner and partner-to-CYP3A4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP3A4 versus CRYBG3 in LSCC, with a Pearson correlation of -0.26.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A4→partner) and Y-score (partner→CYP3A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CRYBG3 →	-0.252	-0.159	<.001	.007	3	5
HNSC	NRBF2 →	-0.384	-0.429	<.001	.003	3	5
LUAD	PPP1R18_S224 →	-0.602	-0.515	<.001	<.001	3	4
HNSC	PYGL →	-0.455	-0.398	<.001	<.001	3	4
HNSC	RPL18A_S123 →	-0.527	-0.614	<.001	.001	3	4
GBM	COL12A1 →	-0.847	-0.566	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,026 associations by consensus.

CYP3A4 vs CRYBG3 — LSCC

Explore this scatter interactively →