CYP3A4

Across TCGA cell cohorts, CYP3A4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,662 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP3A4-associated GO terms across cancer lineages are Glycerophospholipid biosynthetic process, Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, and Phospholipid biosynthetic process. Each is linked with CYP3A4 in more than 6 cancer types. Because this analysis shows association rather than direction, both CYP3A4-to-partner and partner-to-CYP3A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycerophospholipid biosynthetic process grouped by CYP3A4-low versus CYP3A4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP3A4→partner) and Y-score (partner→CYP3A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Glycerophospholipid biosynthetic process →	+0.018	+0.084	.001	.001	3	7
BLOOD_Leukemia	Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.067	+0.097	<.001	.007	3	7
PANCREAS	Phospholipid biosynthetic process →	+0.039	+0.078	<.001	.004	3	6
BLOOD_Lymphoma	Post-transcriptional gene silencing →	+0.060	+0.036	<.001	<.001	3	6
OVARY	Negative regulation of autophagy →	+0.050	+0.025	.003	.008	3	5
LUNG_NSCLC_LUSC	Oxidative demethylation →	-0.130	-0.067	.006	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,662 associations by consensus.

Glycerophospholipid biosynthetic process by CYP3A4 expression — BLOOD_Leukemia

Explore this box plot interactively →