CYP2W1

Across TCGA patient cohorts, CYP2W1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2W1-associated genes across cancer lineages are Caspase-8, ER-alpha_pS118, and 53BP1. Each is linked with CYP2W1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2W1-to-partner and partner-to-CYP2W1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by CYP2W1-low versus CYP2W1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2W1→partner) and Y-score (partner→CYP2W1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.278	-2.973	.027	.035	3	2
UCEC	ER-alpha_pS118 →	+0.378	+2.820	.036	.035	3	1
UCEC	53BP1 →	+0.431	+2.999	.012	.035	3	1
UCEC	14-3-3_beta →	-0.119	-2.308	.018	.036	2	1
UCEC	PTEN →	-0.488	-2.321	.014	.035	2	1
UCEC	STAT3_pY705 →	-0.368	-2.321	.005	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Caspase-8 by CYP2W1 expression — UCEC

Explore this box plot interactively →