CYP2S1

Across TCGA patient cohorts, CYP2S1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2S1-associated genes across cancer lineages are VHL, FOXO3a_pS318_S321, and INPP4B. Each is linked with CYP2S1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2S1-to-partner and partner-to-CYP2S1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CYP2S1-low versus CYP2S1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2S1→partner) and Y-score (partner→CYP2S1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.462	-1.440	.049	.024	3	2
UCEC	FOXO3a_pS318_S321 →	-0.089	-1.838	.040	.007	3	1
UCEC	INPP4B →	-0.315	-3.807	.004	<.001	3	1
UCEC	JNK2 →	+0.229	+2.459	<.001	<.001	2	2
UCEC	Ku80 →	+0.228	+1.887	.005	.029	3	1
UCEC	MEK1 →	+0.254	+1.765	.045	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

VHL by CYP2S1 expression — UCEC

Explore this box plot interactively →