Across TCGA patient cohorts, CYP2R1 protein abundance is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CYP2R1-associated genes across cancer lineages are TFEB, SLC29A1, and MIS18BP1. Each is linked with CYP2R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2R1-to-partner and partner-to-CYP2R1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2R1→partner) and Y-score (partner→CYP2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TFEB →	+0.993	+0.696	.002	.003	3	1
LUAD	SLC29A1 →	+0.710	+0.636	.008	.005	3	1
LUAD	MIS18BP1 →	-0.580	-0.656	.007	.004	3	1
LUAD	DDX11 →	-0.996	-0.616	.001	.005	3	1
LUAD	MYG1 →	+0.133	+0.686	.005	.004	3	1
LUAD	GTF2E1 →	-0.489	-0.686	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

Exploration

CYP2R1 survival (RNA) · tumor vs normal (RNA) · all CYP2R1 data types