Across TCGA patient cohorts, CYP2R1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2R1-associated genes across cancer lineages are Notch1, EGFR_pY1068, and eIF4E. Each is linked with CYP2R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2R1-to-partner and partner-to-CYP2R1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2R1→partner) and Y-score (partner→CYP2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.240	+2.125	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.242	-1.906	.016	.016	3	1
UCEC	eIF4E →	+0.174	+1.906	.040	.016	3	1
UCEC	JNK_pT183_Y185 →	-0.195	-3.584	.003	.002	3	1
UCEC	MAPK_pT202_Y204 →	-0.371	-1.906	.049	.016	3	1
UCEC	MEK1 →	+0.384	+3.584	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

CYP2R1 survival (RNA) · tumor vs normal (RNA) · all CYP2R1 data types