Across TCGA cell cohorts, CYP2R1 mutation is significantly associated with the mutation status of many other genes, with 2,357 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP2R1-associated genes across cancer lineages are ARHGEF28, MYH4, and DMXL1. Each is linked with CYP2R1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2R1-to-partner and partner-to-CYP2R1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2R1→partner) and Y-score (partner→CYP2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ARHGEF28 →	+3.215	+3.954	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	MYH4 →	+2.731	+4.070	.009	.009	1	3
UPPER_AERODIGESTIVE_TRACT	DMXL1 →	+4.954	+4.392	.008	.008	1	3
LARGE_INTESTINE	INSRR →	+1.951	+3.015	.006	.006	1	3
LARGE_INTESTINE	LRRC7 →	+1.712	+3.676	.003	.003	1	3
LARGE_INTESTINE	MYO9A →	+1.799	+3.769	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,357 associations by consensus.

Exploration

CYP2R1 survival (RNA) · tumor vs normal (RNA) · all CYP2R1 data types