Across TCGA cell cohorts, CYP2R1 mutation is significantly associated with the drug of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP2R1-associated genes across cancer lineages are Zoledronate, Dactinomycin, and 123829. Each is linked with CYP2R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2R1-to-partner and partner-to-CYP2R1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2R1→partner) and Y-score (partner→CYP2R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Zoledronate →	+0.315	+2.649	.024	.046	3	1
LARGE_INTESTINE	Dactinomycin →	+0.645	+2.649	.005	.046	3	1
LARGE_INTESTINE	123829 →	+0.595	+2.649	.041	.046	3	1
LARGE_INTESTINE	50869 →	+0.425	+2.649	.045	.046	3	1
LARGE_INTESTINE	OF-1 →	+0.322	+2.646	.025	.047	3	1
LARGE_INTESTINE	Savolitinib →	+0.407	+2.777	.022	.038	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

CYP2R1 survival (RNA) · tumor vs normal (RNA) · all CYP2R1 data types