CYP2J2

Across TCGA patient cohorts, CYP2J2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2J2-associated genes across cancer lineages are Chk2_pT68, ERK2, and JNK2. Each is linked with CYP2J2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2J2-to-partner and partner-to-CYP2J2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by CYP2J2-low versus CYP2J2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2J2→partner) and Y-score (partner→CYP2J2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.176	-3.143	.022	.018	3	2
UCEC	ERK2 →	+0.188	+3.169	.018	.018	3	1
UCEC	JNK2 →	+0.266	+3.026	.001	.018	3	1
UCEC	Ku80 →	+0.244	+1.884	.012	.030	3	1
UCEC	MEK1 →	+0.471	+2.700	.001	.006	3	1
UCEC	Notch1 →	+0.170	+3.335	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Chk2_pT68 by CYP2J2 expression — UCEC

Explore this box plot interactively →