Across TCGA patient cohorts, CYP2F1 mutation is significantly associated with the RNA expression of many other genes, with 1,714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2F1-associated genes across cancer lineages are ADM, CFAP20, and GOT1. Each is linked with CYP2F1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2F1-to-partner and partner-to-CYP2F1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2F1→partner) and Y-score (partner→CYP2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ADM →	+1.163	+2.106	<.001	.003	3	3
UCEC	CFAP20 →	+0.465	+3.169	<.001	<.001	3	3
UCEC	GOT1 →	+0.361	+2.002	.003	<.001	3	3
UCEC	SRA1 →	+0.266	+2.010	.002	.005	3	3
SKCM	SNORD114-14 →	+0.151	+3.212	<.001	.004	3	3
BRCA	RNA5SP153 →	+0.232	+8.057	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,714 associations by consensus.

Exploration

CYP2F1 survival (RNA) · tumor vs normal (RNA) · all CYP2F1 data types