Across TCGA cell cohorts, CYP2F1 mutation is significantly associated with the RNA expression of many other genes, with 441 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP2F1-associated genes across cancer lineages are GUCA2A, DEPDC5, and MCAT. Each is linked with CYP2F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2F1-to-partner and partner-to-CYP2F1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2F1→partner) and Y-score (partner→CYP2F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1
LARGE_INTESTINE	DEPDC5 →	+0.585	+3.502	.002	.001	3	1
LARGE_INTESTINE	MCAT →	+0.776	+3.404	<.001	<.001	3	1
LARGE_INTESTINE	SAMM50 →	+0.550	+3.064	.001	.009	3	1
LARGE_INTESTINE	TRMU →	+0.646	+3.502	<.001	.001	3	1
LARGE_INTESTINE	MTFMT →	+0.626	+3.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 441 associations by consensus.

Exploration

CYP2F1 survival (RNA) · tumor vs normal (RNA) · all CYP2F1 data types