CYP2E1

Across TCGA pan-cancer cohorts, CYP2E1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CYP2E1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CYP2E1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYP2E1 expression acts as an unfavorable survival marker.

UCEC and LUAD are the cancer types where CYP2E1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.263	1.000	.038	6	view →
LUAD	OS	Median	II,III,IV	0.294	0.738	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

CYP2E1–UCEC (DFS)

Open the UCEC breakdown →