CYP2E1

Across TCGA patient cohorts, CYP2E1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,153 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible CYP2E1-associated GO terms across cancer lineages are Monoterpenoid metabolic process, Peptidyl-lysine methylation, and Negative regulation of mRNA processing. Each is linked with CYP2E1 in more than 26 cancer types. Because this analysis shows association rather than direction, both CYP2E1-to-partner and partner-to-CYP2E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monoterpenoid metabolic process grouped by CYP2E1-low versus CYP2E1-high in MESO.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2E1→partner) and Y-score (partner→CYP2E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	Monoterpenoid metabolic process →	+0.846	+0.457	<.001	<.001	2	27
UVM	Peptidyl-lysine methylation →	+0.044	+0.374	<.001	<.001	3	22
KIRC	Negative regulation of mRNA processing →	+0.070	+0.470	<.001	<.001	3	21
KIRC	Protein methylation →	+0.047	+0.472	<.001	<.001	3	21
UVM	Regulation of DNA strand elongation →	+0.059	+0.407	<.001	<.001	3	21
KIRC	Negative regulation of RNA splicing →	+0.065	+0.473	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,153 associations by consensus.

Monoterpenoid metabolic process by CYP2E1 expression — MESO

Explore this box plot interactively →