CYP2E1

Across TCGA patient cohorts, CYP2E1 mutation is significantly associated with the RNA expression of many other genes, with 4,248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2E1-associated genes across cancer lineages are RN7SL591P, CSGALNACT2P2, and KRTAP1-4. Each is linked with CYP2E1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2E1-to-partner and partner-to-CYP2E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL591P grouped by CYP2E1-low versus CYP2E1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2E1→partner) and Y-score (partner→CYP2E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL591P →	+0.083	+2.434	<.001	.001	3	3
SKCM	CSGALNACT2P2 →	+0.045	+2.807	<.001	.002	3	3
HNSC	KRTAP1-4 →	+0.090	+5.008	.008	.004	3	3
LIHC	H3P42 →	+0.135	+5.033	<.001	.009	3	2
UCEC	SUPV3L1 →	+0.461	+2.711	<.001	<.001	3	2
UCEC	SEC13 →	+0.332	+1.716	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,248 associations by consensus.

RN7SL591P by CYP2E1 expression — SKCM

Explore this box plot interactively →