CYP2E1

Across TCGA cell cohorts, CYP2E1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,187 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP2E1-associated GO terms across cancer lineages are Organohalogen metabolic process, Monoterpenoid metabolic process, and Lipid hydroxylation. Each is linked with CYP2E1 in more than 19 cancer types. Because this analysis shows association rather than direction, both CYP2E1-to-partner and partner-to-CYP2E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Organohalogen metabolic process grouped by CYP2E1-low versus CYP2E1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2E1→partner) and Y-score (partner→CYP2E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Organohalogen metabolic process →	-0.376	-1.124	.005	<.001	3	20
LUNG_SCLC	Monoterpenoid metabolic process →	+0.871	+2.693	.003	<.001	3	13
PANCREAS	Lipid hydroxylation →	+0.959	+1.010	.005	.001	3	7
LUNG_SCLC	Hydrocarbon metabolic process →	+0.525	+1.137	.008	.006	3	7
BREAST	Positive regulation of toll-like receptor signaling pathway →	+0.084	+0.843	.007	.006	3	6
SOFT_TISSUE	Long-chain fatty acid biosynthetic process →	-0.182	-0.955	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,187 associations by consensus.

Organohalogen metabolic process by CYP2E1 expression — OVARY

Explore this box plot interactively →