CYP2E1

Across TCGA cell cohorts, CYP2E1 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP2E1-associated genes across cancer lineages are OR7A10, HBZ, and TAS2R42. Each is linked with CYP2E1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2E1-to-partner and partner-to-CYP2E1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7A10 grouped by CYP2E1-low versus CYP2E1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2E1→partner) and Y-score (partner→CYP2E1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR7A10 →	+0.011	+4.022	<.001	.006	3	1
SKIN	HBZ →	+0.088	+3.453	<.001	.009	3	1
SKIN	TAS2R42 →	+0.050	+3.453	.003	.009	3	1
BLOOD_Lymphoma	NTSR2 →	+0.442	+5.794	<.001	<.001	3	1
BLOOD_Lymphoma	PYDC2 →	+0.110	+5.247	<.001	.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.024	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

OR7A10 by CYP2E1 expression — SKIN

Explore this box plot interactively →