CYP2D6

Across TCGA cell cohorts, CYP2D6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,831 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP2D6-associated GO terms across cancer lineages are Regulation of myoblast fusion, Cilium or flagellum-dependent cell motility, and Viral transcription. Each is linked with CYP2D6 in more than 16 cancer types. Because this analysis shows association rather than direction, both CYP2D6-to-partner and partner-to-CYP2D6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by CYP2D6-low versus CYP2D6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2D6→partner) and Y-score (partner→CYP2D6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of myoblast fusion →	+0.171	+0.819	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.092	-0.614	<.001	.001	3	16
BONE	Viral transcription →	+0.143	+0.928	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.136	-0.916	<.001	<.001	3	16
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.101	+0.718	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.136	-0.916	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,831 associations by consensus.

Regulation of myoblast fusion by CYP2D6 expression — OESOPHAGUS

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