CYP2D6

Across TCGA cell cohorts, CYP2D6 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP2D6-associated genes across cancer lineages are DEFB4A, OR10G2, and GPR101. Each is linked with CYP2D6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2D6-to-partner and partner-to-CYP2D6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB4A grouped by CYP2D6-low versus CYP2D6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2D6→partner) and Y-score (partner→CYP2D6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DEFB4A →	+0.088	+3.362	<.001	.001	3	2
BLOOD_Leukemia	OR10G2 →	+0.732	+3.288	<.001	<.001	3	2
URINARY_TRACT	GPR101 →	+0.020	+5.087	<.001	.004	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR52H1 →	+0.031	+4.669	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

DEFB4A by CYP2D6 expression — BLOOD_Leukemia

Explore this box plot interactively →