CYP2D6

Across TCGA cell cohorts, CYP2D6 mutation is significantly associated with the mutation status of many other genes, with 3,505 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP2D6-associated genes across cancer lineages are SIN3B, TTBK2, and PDE4A. Each is linked with CYP2D6 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP2D6-to-partner and partner-to-CYP2D6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIN3B grouped by CYP2D6-low versus CYP2D6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2D6→partner) and Y-score (partner→CYP2D6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SIN3B →	+2.498	+2.624	.008	.008	1	4
BLOOD_Lymphoma	TTBK2 →	+4.429	+5.247	.005	.005	1	3
BLOOD_Leukemia	PDE4A →	+2.820	+3.080	.001	.001	1	3
BLOOD_Leukemia	STAG3 →	+2.498	+2.624	.008	.008	1	3
BLOOD_Leukemia	SMARCA2 →	+2.913	+2.913	.003	.003	1	3
LARGE_INTESTINE	ZBED4 →	+1.874	+3.700	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,505 associations by consensus.

SIN3B by CYP2D6 expression — BLOOD_Leukemia

Explore this box plot interactively →