CYP2C9

Across TCGA patient cohorts, CYP2C9 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,974 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible CYP2C9-associated GO terms across cancer lineages are Glycerophospholipid biosynthetic process, Oxidative demethylation, and Phospholipid biosynthetic process. Each is linked with CYP2C9 in more than 14 cancer types. Because this analysis shows association rather than direction, both CYP2C9-to-partner and partner-to-CYP2C9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycerophospholipid biosynthetic process grouped by CYP2C9-low versus CYP2C9-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C9→partner) and Y-score (partner→CYP2C9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Glycerophospholipid biosynthetic process →	+0.040	+1.068	<.001	<.001	3	15
HNSC	Oxidative demethylation →	-0.074	-0.476	<.001	<.001	3	14
ESCA	Phospholipid biosynthetic process →	+0.041	+1.094	<.001	<.001	3	14
STAD	Preassembly of GPI anchor in ER membrane →	+0.032	+0.551	<.001	<.001	3	14
ESCA	Nucleoside bisphosphate biosynthetic process →	+0.039	+1.034	<.001	<.001	3	14
CHOL	Primary alcohol metabolic process →	+0.088	+3.938	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,974 associations by consensus.

Glycerophospholipid biosynthetic process by CYP2C9 expression — ESCA

Explore this box plot interactively →