CYP2C9

Across TCGA patient cohorts, CYP2C9 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2C9-associated genes across cancer lineages are ERCC1, PCNA, and PKC-b-II_pS660. Each is linked with CYP2C9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2C9-to-partner and partner-to-CYP2C9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERCC1 grouped by CYP2C9-low versus CYP2C9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C9→partner) and Y-score (partner→CYP2C9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERCC1 →	+0.093	+1.223	.040	.005	3	2
UCEC	PCNA →	+0.228	+2.807	.004	.003	3	2
UCEC	PKC-b-II_pS660 →	-0.203	-1.502	.045	.030	3	2
UCEC	ATM →	-0.617	-2.736	<.001	<.001	3	2
UCEC	MEK1 →	+0.298	+2.247	.026	.001	3	2
UCEC	p62 Lck ligand →	+0.350	+2.736	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ERCC1 by CYP2C9 expression — SKCM

Explore this box plot interactively →