CYP2C9

Across TCGA cell cohorts, CYP2C9 RNA expression is significantly associated with the go_rna of many other GO terms, with 711 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CYP2C9-associated GO terms across cancer lineages are Organohalogen metabolic process, Adenylate cyclase-activating serotonin receptor signaling pathway, and Regulation of myoblast fusion. Each is linked with CYP2C9 in more than 5 cancer types. Because this analysis shows association rather than direction, both CYP2C9-to-partner and partner-to-CYP2C9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Organohalogen metabolic process grouped by CYP2C9-low versus CYP2C9-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C9→partner) and Y-score (partner→CYP2C9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Organohalogen metabolic process →	-0.268	-1.492	<.001	<.001	2	6
LIVER	Adenylate cyclase-activating serotonin receptor signaling pathway →	+0.174	+1.122	<.001	.008	2	5
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.064	+0.063	.005	.009	3	4
LUNG_SCLC	Receptor diffusion trapping →	-1.454	-0.233	<.001	.009	3	4
LUNG_SCLC	Postsynaptic neurotransmitter receptor diffusion trapping →	-1.454	-0.233	<.001	.009	3	4
LUNG_SCLC	Neurotransmitter receptor diffusion trapping →	-1.454	-0.233	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 711 associations by consensus.

Organohalogen metabolic process by CYP2C9 expression — STOMACH

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