CYP2C8

Across TCGA pan-cancer cohorts, CYP2C8 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CYP2C8 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CYP2C8 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CYP2C8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, COAD, and LGG are the cancer types where CYP2C8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.436	.012	18	view →
COAD	OS	Median	III,IV	0.056	0.783	<.001	12	view →
LGG	DFS	Median	All	0.083	0.826	<.001	6	view →
LIHC	DFS	Median	III,IV	0.046	0.361	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.823	0.657	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CYP2C8–UCEC (DFS)

Open the UCEC breakdown →