CYP2C8

Across TCGA patient cohorts, CYP2C8 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,133 significant associations in total. THCA shows the largest number of these associations.

The most reproducible CYP2C8-associated GO terms across cancer lineages are Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway, Macromolecule deacylation, and Obsolete histone methylation. Each is linked with CYP2C8 in more than 23 cancer types. Because this analysis shows association rather than direction, both CYP2C8-to-partner and partner-to-CYP2C8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway grouped by CYP2C8-low versus CYP2C8-high in UVM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C8→partner) and Y-score (partner→CYP2C8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.064	+0.148	<.001	<.001	3	23
UVM	Macromolecule deacylation →	+0.037	+0.146	<.001	<.001	3	23
SCLC	Obsolete histone methylation →	+0.122	+0.775	.003	.007	2	24
UVM	Methylation →	+0.040	+0.174	<.001	<.001	3	23
STAD	Organelle disassembly →	+0.064	+0.321	<.001	<.001	3	22
STAD	Vacuolar transport →	+0.066	+0.291	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,133 associations by consensus.

Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway by CYP2C8 expression — UVM

Explore this box plot interactively →