CYP2C8

Across TCGA patient cohorts, CYP2C8 mutation is significantly associated with the RNA expression of many other genes, with 2,067 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CYP2C8-associated genes across cancer lineages are ZNF885P, RNU6-1078P, and DEFB131A. Each is linked with CYP2C8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2C8-to-partner and partner-to-CYP2C8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF885P grouped by CYP2C8-low versus CYP2C8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C8→partner) and Y-score (partner→CYP2C8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ZNF885P →	+0.030	+1.322	.008	.003	3	3
HNSC	RNU6-1078P →	+0.278	+7.954	<.001	.008	3	2
LUAD	DEFB131A →	+1.559	+4.410	<.001	.001	3	2
LUAD	CRLF3P1 →	+0.030	+4.712	<.001	<.001	3	2
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
UCEC	FAM177A1 →	+0.388	+2.732	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,067 associations by consensus.

ZNF885P by CYP2C8 expression — SKCM

Explore this box plot interactively →