CYP2C8

Across TCGA patient cohorts, CYP2C8 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2C8-associated genes across cancer lineages are HSP70, STAT3_pY705, and Caspase-8. Each is linked with CYP2C8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2C8-to-partner and partner-to-CYP2C8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by CYP2C8-low versus CYP2C8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C8→partner) and Y-score (partner→CYP2C8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSP70 →	-0.409	-2.105	.009	.017	3	2
UCEC	STAT3_pY705 →	-0.409	-2.896	<.001	.001	3	2
UCEC	Caspase-8 →	-0.277	-3.780	.004	<.001	3	2
SKCM	GAPDH →	+0.462	+1.125	.009	.030	3	2
UCEC	EGFR_pY1068 →	-0.308	-3.459	.001	.005	3	1
UCEC	FASN →	+0.350	+2.115	.023	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

HSP70 by CYP2C8 expression — UCEC

Explore this box plot interactively →