CYP2C8

Across TCGA cell cohorts, CYP2C8 RNA expression is significantly associated with the go_rna of many other GO terms, with 827 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CYP2C8-associated GO terms across cancer lineages are Oxidative demethylation, Demethylation, and Negative regulation of respiratory burst involved in inflammatory response. Each is linked with CYP2C8 in more than 7 cancer types. Because this analysis shows association rather than direction, both CYP2C8-to-partner and partner-to-CYP2C8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oxidative demethylation grouped by CYP2C8-low versus CYP2C8-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C8→partner) and Y-score (partner→CYP2C8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Oxidative demethylation →	-0.265	-0.230	.008	<.001	3	8
URINARY_TRACT	Demethylation →	-0.142	-0.216	<.001	.001	3	6
BREAST	Negative regulation of respiratory burst involved in inflammatory response →	+0.085	+0.112	.002	.008	2	6
BREAST	Negative regulation of respiratory burst →	+0.085	+0.112	.002	.008	2	6
BLOOD_Myeloma	Nucleobase-containing compound transport →	+0.045	+0.618	<.001	<.001	3	5
BREAST	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.049	+0.216	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 827 associations by consensus.

Oxidative demethylation by CYP2C8 expression — URINARY_TRACT

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