CYP2C8

Across TCGA cell cohorts, CYP2C8 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYP2C8-associated genes across cancer lineages are GZMK, AIPL1, and OCM2. Each is linked with CYP2C8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP2C8-to-partner and partner-to-CYP2C8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by CYP2C8-low versus CYP2C8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C8→partner) and Y-score (partner→CYP2C8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GZMK →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	AIPL1 →	+0.100	+3.554	<.001	.007	3	1
LARGE_INTESTINE	OCM2 →	+0.055	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GPR6 →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.034	+3.584	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.043	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GZMK by CYP2C8 expression — LARGE_INTESTINE

Explore this box plot interactively →