CYP2C19

Across TCGA patient cohorts, CYP2C19 RNA expression is significantly associated with the protein abundance of many other proteins, with 6,296 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CYP2C19-associated proteins across cancer lineages are CAMSAP3, EPB41L1, and FAM83E_S351. Each is linked with CYP2C19 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP2C19-to-partner and partner-to-CYP2C19 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP2C19 versus CAMSAP3 in HNSC, with a Pearson correlation of 0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C19→partner) and Y-score (partner→CYP2C19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CAMSAP3 →	+0.381	+0.499	<.001	<.001	3	4
HNSC	EPB41L1 →	+0.843	+0.744	<.001	<.001	3	4
PDAC	FAM83E_S351 →	+1.004	+0.746	<.001	<.001	3	4
HNSC	GPX2 →	+1.249	+0.468	<.001	.003	3	4
LSCC	TACC2_S962 →	+0.830	+0.416	<.001	<.001	3	4
LSCC	PXN_S322 →	-0.395	-0.334	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,296 associations by consensus.

CYP2C19 vs CAMSAP3 — HNSC

Explore this scatter interactively →