CYP2C19

Across TCGA patient cohorts, CYP2C19 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP2C19-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and AMPK_alpha. Each is linked with CYP2C19 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP2C19-to-partner and partner-to-CYP2C19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by CYP2C19-low versus CYP2C19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C19→partner) and Y-score (partner→CYP2C19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.424	-1.794	.022	.027	3	3
UCEC	PCNA →	+0.243	+3.459	.006	.005	3	2
SKCM	AMPK_alpha →	+0.082	+1.247	.028	.034	3	2
UCEC	Cyclin-B1 →	+0.768	+2.321	<.001	.006	3	2
UCEC	Ku80 →	+0.280	+2.335	.004	.003	3	2
UCEC	Notch1 →	+0.156	+2.335	.007	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

p38-MAPK_pT180_Y182 by CYP2C19 expression — UCEC

Explore this box plot interactively →