CYP2C19

Across TCGA cell cohorts, CYP2C19 RNA expression is significantly associated with the go_rna of many other GO terms, with 528 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible CYP2C19-associated GO terms across cancer lineages are Negative regulation of CD8-positive, alpha-beta T cell differentiation, Lipid hydroxylation, and Cortical actin cytoskeleton organization. Each is linked with CYP2C19 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP2C19-to-partner and partner-to-CYP2C19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of CD8-positive, alpha-beta T cell differentiation grouped by CYP2C19-low versus CYP2C19-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP2C19→partner) and Y-score (partner→CYP2C19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of CD8-positive, alpha-beta T cell differentiation →	+0.237	+0.044	<.001	<.001	3	4
LIVER	Lipid hydroxylation →	+1.349	+0.543	<.001	.005	3	4
STOMACH	Cortical actin cytoskeleton organization →	+0.083	+0.802	.007	.005	3	4
LIVER	Positive regulation of flagellated sperm motility involved in capacitation →	+1.557	+0.516	<.001	.008	3	4
LUNG_NSCLC_LUSC	Nuclear pore complex assembly →	+0.088	+0.043	.004	.004	3	3
STOMACH	Purkinje myocyte to ventricular cardiac muscle cell communication →	+0.883	+1.026	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 528 associations by consensus.

Negative regulation of CD8-positive, alpha-beta T cell differentiation by CYP2C19 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →